In 1987, school-based health centers opened in Istrouma High School and Westdale Middle School, marking the beginning of the partnership between East Baton Rouge Parish School System (EBRPSS) and Health Centers in Schools (HCS). In 1993, two more school health centers were added at Prescott Middle School and Glen Oaks Middle School. All four school sites were chosen because of community interest, school administration interest and findings that many students were uninsured or under-insured and lacked access to primary health care. Expansion of the partnership continued in 1997 when school-based health centers were opened in Glen Oaks High School, Northeast Elementary School and Northeast High School. In 2001, Capitol High School Health Center was re-opened under the direction of HCS.

The vote of the school board in 2004 that approved Health Centers in Schools as the manager of the school nurse program, and most recently, the school board voted in July 2008 to build eight additional health centers over the next four years. Construction was completed on the first two that opened for the 2009-10 school year at Broadmoor High and Glasgow Middle Schools. With the changes in the EBR school system and some schools going to the Recovery District or being closed, several health centers were closed. HCS now manages health centers at 7 schools in EBR parish, and 2 remain open year-round at Broadmoor High and Glen Oaks High to serve adolescents ages 11-22.

Today HCS and its staff of physicians, nurse practitioners, registered nurses, medical assistants, social workers, administrators and contract personnel work to deliver primary preventive health care to the children who are enrolled in these schools. The primary funding source for this initiative is the Louisiana Office of Public Health (OPH), a division of the Louisiana Department of Health and Hospitals. About 30% of the over $ 3.9 million budget of HCS comes from contracts with OPH with the other 40% from more than thirty partners who believe in our vision, mission, and values.